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KMID : 0624620110440110741
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BMB Reports
2011 Volume.44 No. 11 p.741 ~ p.746
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Linkage and association scan for tanning ability in an isolated Mongolian population
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Paik Seung-Hwan
Kim Hyun-Jin
Lee Seung-Bok
Im Sun-Wha
Ju Young-Seok
Yeon Je-Ho
Jo Seong-Jin
Eun Hee-Chul
Seo Jeong-Sun
Kim Jong-Il
Kwon Oh-Sang
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Abstract
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Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultative and constitutive skin color, respectively. In our study population consisting of isolated Mongolian subjects, with common histories of environmental UV exposure during their nomadic life, facultative skin color adjusted by constitutive skin color was used to indicate tanning ability. Through linkage analysis and family-based association tests of 345 Mongolian subjects, we identified 2 potential linkage regions regulating tanning ability on 5q35.3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17.
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KEYWORD
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Genetic association study, Linkage analysis, Microsatellite repeats, Single nucleotide polymorphism, Tanning
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